Incorporating assessment of fibrinogen gene polymorphisms and bleeding risk in patients treated with direct oral anticoagulants
نویسندگان
چکیده
Direct oral anticoagulants (DOACs) have become entrenched as the dominant anticoagulant over last decade for patients with venous thrombosis and atrial fibrillation.1 Compared to warfarin, bleeding risk is similar or lower on DOACs but clinically relevant still a risk, especially impaired organ function.2
منابع مشابه
Management of bleeding in patients treated with direct oral anticoagulants
BACKGROUND Recently, a new generation of direct-acting oral anticoagulants (DOACs) with a greater specificity towards activated coagulation factors was introduced based on encouraging results for efficacy and safety in clinical studies. An initial limitation of these new drugs was the absence of an adequate strategy to reverse the effect if a bleeding event occurs or an urgent invasive procedur...
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Direct oral anticoagulants (DOACs) are recognized by evidence-based treatment guidelines as the first-line option for the treatment of venous thromboembolism and prevention of stroke and systemic embolism in nonvalvular atrial fibrillation. As use of these anticoagulants has become favored over the past several years, reported bleeding-related adverse drug events with these agents has increased...
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15 صفحه اولBleeding complications from the direct oral anticoagulants
BACKGROUND Direct oral anticoagulants (DOACs) are now standard of care for the management of thromboembolic risk. A prevalent issue of concern is how to manage direct oral anticoagulant (DOAC)-associated bleeding for which there is no specific antidote available for clinical use. We conducted a retrospective case series to describe the Toronto, Canada multicenter experience with bleeding from d...
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ژورنال
عنوان ژورنال: Annals Academy of Medicine Singapore
سال: 2023
ISSN: ['0304-4602']
DOI: https://doi.org/10.47102/annals-acadmedsg.2023233